a-ketoglutarate dehydrogenase

STEP 4
a-ketoglutarate dehydrogenase complex

Similar to pyruvate dehydrogenase multienzyme complex.
High-energy products are also similar: NADH and a thioester (succinyl CoA)

DG = - 43.9 kJ/mol

DGº' = -30 kJ/mol

K_eq = 1.8 ·10^-5

dihydrolipoamide succinyltransferase

dihydrolipoamide dehydrogenase
(identical to that in PDH)

substrate: a-ketoglutarate (CO₂CH₂CH₂COCO₂)

product: succinyl-CoA (CO₂CH₂CH₂CO-SCoA)

		Citric Acid Cycle
		Heather Shepheard
		Tainted by Chemical X
		dihydrolipoamide succinyltransferase
		dihydrolipoamide dehydrogenase